Arne Slot promised a completely changed lineup for Liverpool’s Carabao Cup tie against Southampton, and he has delivered exactly that ,11 changes from the side that beat Everton in the Merseyside derby.
With three matches played in the space of seven days, Slot had rotated lightly, averaging just over two changes per game. But with Championship opposition arriving at Anfield, Softfootball understands that the Dutchman has opted to give several first-team stars a well-earned rest, including Virgil van Dijk, Ryan Gravenberch, and Mohamed Salah, however as reported in the games preview, the Dutch manager has unleashed Aleksander Isak.
Liverpool’s official starting XI as uploaded on the teams official X handle:
The Reds to take on Southampton 🔴
— Liverpool FC (@LFC) September 23, 2025
It is, instead, a night for Liverpool’s squad depth to step up. New signing Giorgi Mamardashvili makes his competitive debut in goal, with Giovanni Leoni also handed his first start. Jeremie Frimpong, Joe Gomez, and Andy Robertson complete the backline.’
In midfield, Wataru Endo returns for his first start of the campaign, supported by Curtis Jones and youngster Trey Nyoni, who continues to earn the trust of the manager. Up front, Alexander Isak will be desperate to open his Liverpool account, flanked by Federico Chiesa and academy product Rio Ngumoha.

On the bench, there’s still plenty of firepower should it be needed. Milos Kerkez, Conor Bradley, and Hugo Ekitike provide senior options, while Kieran Morrison, Kaide Gordon, and Jayden Danns represent the next generation of Reds talent.
Southampton’s official starting Xi Uploaded via the clubs X handle:
Your YELLOWS 💛 pic.twitter.com/klpBTyI8cq
— Southampton FC (@SouthamptonFC) September 23, 2025
For Southampton, it’s another trip to Anfield with yet another new face in the dugout. Remarkably, this will be the Saints’ fifth consecutive visit to Liverpool with a different manager in charge. Since November 2021, they’ve arrived under Ivan Juric, Russell Martin, Nathan Jones, and Ralph Hasenhüttl. This time it’s Will Still who takes the reins, with former Liverpool midfielder Adam Lallana now part of his backroom staff.